Impact of Hydroxyurea on Blood Transfusion Rate in Patients of Beta-Thalassemia Major

Objective: To determine the effectiveness of hydroxyurea on blood transfusion rate in patients with beta-thalassemia major.
 Materials and Methods: This cross-sectional study was held Department Genetics Molecular Biology/Pathology at LUMHS Jamshoro, Diagnostic Research Laboratory, Hyderabad, Sindh from February 2015 to August 2015. Patients beta thalassaemia major, diagnosed Hb electrophoresis, who had less than 7 g/dl were regularly transfused every two four weeks included. divided into groups equal numbers. Half underwent treatment half without hydroxyurea. In comparison those did not receive treatment. The ability keep haemoglobin levels over 9 or a lowering least 50% initial needs considered signs therapeutic success. Data entered analyzed using SPSS 26.
 Results: mean age 11.02+3.93 years males majority (68.0%). 56.2% cases, there positive family history. serum ferritin level 12824.39+300.60 ng/ml 7.52+1.67 gm/dl. Some report follow-up, because some families migrated other areas Sindh, cases went welfare hospitals/ centers, for Therefore, out 40 patients, 30 observed hydroxyurea, overall, this showed significant decrease requirements (P-0.01).
 Conclusion: As per study’s conclusion, be most effective rate, but should treated under proper responsible observation.